Cellix worked on the development of a novel microfluidic biochip and assay development to enable researchers to investigate cellular uptake of nanoparticles in endothelial cells under defined shear stresses (flow rates) mimicking those found in vivo. Below are a sample of some of the results:
Cellular uptake of CdTe QDs by human endothelial cells under various shear stresses:
Cellular uptake of silica NPs by human endothelial cells under various shear stresses: CdTe QDs, but not silica NPs, influence viability of human endothelial cells:
*SFI provides grants for researchers from around the world who wish to relocate to Ireland and those already based in Ireland, for outstanding investigators, for conferences and symposia, and for collaboration with industry. The majority of SFI awards are in the fields of science and engineering underpinning three Government-prioritised industrial sectors: biotechnology (Bio), information and communications technology (ICT) and sustainable energy and energy-efficient technologies.
At a smaller scale SFI also supports a broad range of disciplines in Science, Mathematics and Engineering via its Research Frontiers Programme. Proposals are evaluated in open competitions via a combination of international peer review and strategic fit with SFI’s mission